VHL Ligand 8

• CAT Number: I046008
• CAS Number: 2701565-76-4
• Molecular Formula: C23H29N3O6
• Molecular Weight: 443.49
• Purity: ≥95%
• Synonyms: (3S)-3-[[(2S,4R)-4-hydroxy-1-[(2R)-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid
• InChI: InChI=1S/C23H29N3O6/c1-13(2)21(19-9-14(3)25-32-19)23(31)26-12-16(27)10-18(26)22(30)24-17(11-20(28)29)15-7-5-4-6-8-15/h4-9,13,16-18,21,27H,10-12H2,1-3H3,(H,24,30)(H,28,29)/t16-,17+,18+,21-/m1/s1
• InChIKey: BYUIKERVKHGIMC-OEMYIYORSA-N
• SMILES: CC1=NOC(=C1)C(C(C)C)C(=O)N2CC(CC2C(=O)NC(CC(=O)O)C3=CC=CC=C3)O

VHL Ligand 8(CAT: I046008) is a synthetic ligand for the von Hippel–Lindau (VHL) E3 ubiquitin ligase, widely used as a building block in the design of proteolysis-targeting chimeras (PROTACs). It enables recruitment of the VHL E3 ligase to targeted proteins, promoting their ubiquitination and proteasomal degradation. VHL Ligand 8 is a key precursor for the synthesis of ARD-266 (HY-133020), a highly potent VHL-based androgen receptor (AR) degrader that induces AR degradation in prostate cancer cell lines (DC50 = 0.2–1 nM). This ligand is a versatile chemical biology tool for targeted protein degradation and PROTAC drug discovery.