For research use only. Not for therapeutic Use.
VH032-PEG3-acetylene（Cat No.:I017829）is a bifunctional chemical probe based on the VHL (von Hippel–Lindau) E3 ligase ligand VH032, commonly used in targeted protein degradation research. The PEG3 spacer improves solubility and flexibility, while the terminal acetylene group enables bio-orthogonal conjugation through click chemistry. This design allows researchers to link VH032 to diverse functional groups, fluorophores, or warheads for proteolysis-targeting chimera (PROTAC) development. VH032-PEG3-acetylene is widely applied in chemical biology to study protein–ligase interactions, validate PROTAC design strategies, and advance targeted degradation approaches in drug discovery.
| CAS Number | 2098799-80-3 |
| Synonyms | (2S,4R)-1-[(2S)-3,3-dimethyl-2-[[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]acetyl]amino]butanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide |
| Molecular Formula | C31H42N4O7S |
| Purity | ≥95% |
| IUPAC Name | (2S,4R)-1-[(2S)-3,3-dimethyl-2-[[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]acetyl]amino]butanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide |
| InChI | InChI=1S/C31H42N4O7S/c1-6-11-40-12-13-41-14-15-42-19-26(37)34-28(31(3,4)5)30(39)35-18-24(36)16-25(35)29(38)32-17-22-7-9-23(10-8-22)27-21(2)33-20-43-27/h1,7-10,20,24-25,28,36H,11-19H2,2-5H3,(H,32,38)(H,34,37)/t24-,25+,28-/m1/s1 |
| InChIKey | HHXQNDSXTCIWSG-CERRFVOPSA-N |
| SMILES | CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)COCCOCCOCC#C)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
