Veliflapon

• CAT Number: M117956
• CAS Number: 128253-31-6
• Molecular Formula: C23H23NO3
• Molecular Weight: 361.43
• Purity: ≥95%
• Synonyms: (2R)-2-cyclopentyl-2-[4-(quinolin-2-ylmethoxy)phenyl]acetic acid
• InChI: InChI=1S/C23H23NO3/c25-23(26)22(17-6-1-2-7-17)18-10-13-20(14-11-18)27-15-19-12-9-16-5-3-4-8-21(16)24-19/h3-5,8-14,17,22H,1-2,6-7,15H2,(H,25,26)/t22-/m1/s1
• InChIKey: ZEYYDOLCHFETHQ-JOCHJYFZSA-N
• SMILES: C1CCC(C1)C(C2=CC=C(C=C2)OCC3=NC4=CC=CC=C4C=C3)C(=O)O

Veliflapon(CAT: M117956) (BAY x 1005) is a potent, selective, and orally active 5-lipoxygenase-activating protein (FLAP) inhibitor. By blocking FLAP, Veliflapon prevents leukotriene biosynthesis, thereby reducing inflammation, bronchoconstriction, and immune cell recruitment. It has been investigated for the treatment of asthma, allergic conditions, and cardiovascular inflammation, highlighting its therapeutic potential in diseases driven by leukotriene overproduction. Preclinical and clinical studies demonstrate that Veliflapon effectively lowers leukotriene levels while maintaining a favorable safety profile. As a targeted anti-inflammatory research compound, Veliflapon is a valuable tool for exploring respiratory disease, cardiovascular inflammation, and immunology-related therapeutic strategies.