For research use only. Not for therapeutic Use.
VEGFR-2-IN-6 (Cat No.: I045449) is a potent, selective inhibitor of vascular endothelial growth factor receptor 2 (VEGFR-2), a key receptor tyrosine kinase mediating angiogenesis through endothelial cell proliferation, migration, and survival. By blocking VEGFR-2 phosphorylation and downstream signaling pathways such as MAPK and PI3K/Akt, it suppresses new blood vessel formation, thereby inhibiting tumor growth and metastasis. VEGFR-2-IN-6 is used in cancer and vascular biology research to study angiogenic signaling and develop targeted anti-angiogenic therapies for oncology and ocular diseases like age-related macular degeneration.
| CAS Number | 444731-47-9 |
| Synonyms | 2-methyl-5-[[4-[methyl-(3-methyl-2H-indazol-6-yl)amino]pyrimidin-2-yl]amino]benzenesulfonamide |
| Molecular Formula | C20H21N7O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C20H21N7O2S/c1-12-4-5-14(10-18(12)30(21,28)29)23-20-22-9-8-19(24-20)27(3)15-6-7-16-13(2)25-26-17(16)11-15/h4-11H,1-3H3,(H,25,26)(H2,21,28,29)(H,22,23,24) |
| InChIKey | BRBRXNGJZMGEHY-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NNC(=C4C=C3)C)S(=O)(=O)N |
| Reference | [1]. Glaxo Wellcome House, et al. PYRIMIDINEAMINES AS ANGIOGENESIS MODULATORS. Patent WO 02/059110. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
