For research use only. Not for therapeutic Use.
Vazegepant（Cat No.:I044522）is a small-molecule, calcitonin gene-related peptide (CGRP) receptor antagonist developed for the acute and preventive treatment of migraine. It works by blocking the CGRP receptor, a key player in migraine pathophysiology, thereby reducing inflammation and vasodilation associated with migraine attacks. Administered intranasally, vazegepant offers rapid onset of action and is effective even when oral medications are not ideal due to nausea or vomiting. It has demonstrated efficacy in clinical trials with a favorable safety profile, making it a valuable non-oral option for migraine management in both acute and chronic cases.
| CAS Number | 1337918-83-8 |
| Synonyms | N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl]-4-(2-oxo-1H-quinolin-3-yl)piperidine-1-carboxamide |
| Molecular Formula | C36H46N8O3 |
| Purity | ≥95% |
| IUPAC Name | N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl]-4-(2-oxo-1H-quinolin-3-yl)piperidine-1-carboxamide |
| InChI | InChI=1S/C36H46N8O3/c1-24-19-25(20-28-23-37-40-33(24)28)21-32(35(46)43-17-15-42(16-18-43)29-9-11-41(2)12-10-29)39-36(47)44-13-7-26(8-14-44)30-22-27-5-3-4-6-31(27)38-34(30)45/h3-6,19-20,22-23,26,29,32H,7-18,21H2,1-2H3,(H,37,40)(H,38,45)(H,39,47)/t32-/m1/s1 |
| InChIKey | JJVAPHYEOZSKJZ-JGCGQSQUSA-N |
| SMILES | CC1=CC(=CC2=C1NN=C2)C[C@H](C(=O)N3CCN(CC3)C4CCN(CC4)C)NC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
