Valemetostat tosylate

For research use only. Not for therapeutic Use.

  • CAT Number: I018290
  • CAS Number: 1809336-93-3
  • Molecular Formula: C33H42ClN3O7S
  • Molecular Weight: 660.22
  • Purity: ≥95%
Inquiry Now

Valemetostat tosylate(Cat No.:I018290)is a potent, selective dual inhibitor of histone methyltransferases EZH1 and EZH2, key components of the polycomb repressive complex 2 (PRC2) involved in epigenetic gene silencing. Dysregulation of EZH1/2 contributes to oncogenesis by repressing tumor suppressor genes. By blocking their methyltransferase activity, valemetostat reactivates silenced genes, promoting cancer cell differentiation and apoptosis. It has shown clinical efficacy in treating adult T-cell leukemia/lymphoma (ATL) and other hematologic malignancies. As an approved targeted epigenetic therapy in Japan, it represents a major advance in precision oncology.


CAS Number 1809336-93-3
Synonyms

(2R)-7-chloro-2-[4-(dimethylamino)cyclohexyl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2,4-dimethyl-1,3-benzodioxole-5-carboxamide;4-methylbenzenesulfonic acid

Molecular Formula C33H42ClN3O7S
Purity ≥95%
IUPAC Name (2R)-7-chloro-2-[4-(dimethylamino)cyclohexyl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2,4-dimethyl-1,3-benzodioxole-5-carboxamide;4-methylbenzenesulfonic acid
InChI InChI=1S/C26H34ClN3O4.C7H8O3S/c1-14-11-15(2)29-25(32)20(14)13-28-24(31)19-12-21(27)23-22(16(19)3)33-26(4,34-23)17-7-9-18(10-8-17)30(5)6;1-6-2-4-7(5-3-6)11(8,9)10/h11-12,17-18H,7-10,13H2,1-6H3,(H,28,31)(H,29,32);2-5H,1H3,(H,8,9,10)/t17?,18?,26-;/m1./s1
InChIKey JSBKGJUYSLVFPF-RRKMXGHKSA-N
SMILES CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC(=C(C(=O)N1)CNC(=O)C2=CC(=C3C(=C2C)O[C@@](O3)(C)C4CCC(CC4)N(C)C)Cl)C
Chemistry Calculators Dilution Calculator
In vivo Formulation Calculator
Molarity Calculator
Molecular Weight Calculator
Reconstitution Calculator

Request a Quote