Val-Cit

• CAT Number: I016150
• CAS Number: 159858-33-0
• Molecular Formula: C11H22N4O4
• Molecular Weight: 274.32
• Purity: ≥95%
• Synonyms: (2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-5-(carbamoylamino)pentanoic acid
• InChI: InChI=1S/C11H22N4O4/c1-6(2)8(12)9(16)15-7(10(17)18)4-3-5-14-11(13)19/h6-8H,3-5,12H2,1-2H3,(H,15,16)(H,17,18)(H3,13,14,19)/t7-,8-/m0/s1
• InChIKey: AGGWFDNPHKLBBV-YUMQZZPRSA-N
• SMILES: CC(C)[C@@H](C(=O)N[C@@H](CCCNC(=O)N)C(=O)O)N

Val-Cit (Cat No.:I016150) is a dipeptide linker widely used in the design of antibody–drug conjugates (ADCs) and targeted drug delivery systems. It is specifically cleaved by cathepsin B and related proteases inside lysosomes, enabling selective release of cytotoxic payloads within tumor cells. This protease-sensitive mechanism ensures high stability in circulation while providing tumor-specific activation. Val-Cit linkers are often combined with self-immolative spacers, such as para-aminobenzyl (PAB), to facilitate efficient drug release. Their reliability and selectivity make them essential tools in therapeutic research and precision oncology.