UZH1a

• CAT Number: I044554
• CAS Number: 2813577-78-3
• Molecular Formula: C32H42N6O3
• Molecular Weight: 558.71
• Purity: ≥95%
• Synonyms: N-[[(3R)-1-[6-(benzylamino)pyrimidin-4-yl]-3-hydroxypiperidin-3-yl]methyl]-4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-hydroxybenzamide
• InChI: InChI=1S/C32H42N6O3/c1-31(2)12-15-37(16-13-31)20-25-9-10-26(27(39)17-25)30(40)34-21-32(41)11-6-14-38(22-32)29-18-28(35-23-36-29)33-19-24-7-4-3-5-8-24/h3-5,7-10,17-18,23,39,41H,6,11-16,19-22H2,1-2H3,(H,34,40)(H,33,35,36)/t32-/m1/s1
• InChIKey: PWYRDVXYAOGDNK-JGCGQSQUSA-N
• SMILES: CC1(CCN(CC1)CC2=CC(=C(C=C2)C(=O)NC[C@@]3(CCCN(C3)C4=NC=NC(=C4)NCC5=CC=CC=C5)O)O)C

UZH1a（Cat No.:I044554）is a selective small-molecule inhibitor of ALKBH5, an m6A RNA demethylase involved in regulating RNA metabolism, gene expression, and cell differentiation. By inhibiting ALKBH5, UZH1a increases N6-methyladenosine (m6A) levels on target RNAs, affecting their stability, splicing, and translation. It demonstrates good cellular permeability and target engagement, serving as an effective chemical probe for studying epitranscriptomic regulation. UZH1a is particularly valuable in cancer and stem cell research, where altered m6A dynamics influence tumorigenesis and cell fate decisions. Its specificity enables detailed exploration of ALKBH5-dependent RNA modifications.