For research use only. Not for therapeutic Use.
Utreglutide（Cat No.:I044224）is a synthetic glucagon-like peptide-2 (GLP-2) analog designed to enhance intestinal growth and function. By binding to the GLP-2 receptor, utreglutide stimulates intestinal epithelial proliferation, improves nutrient absorption, and enhances mucosal barrier integrity. It is primarily investigated for treating short bowel syndrome (SBS) and other conditions involving intestinal failure or damage. Utreglutide’s extended half-life compared to native GLP-2 makes it suitable for therapeutic use. Its targeted action on the gut epithelium offers potential benefits in reducing parenteral nutrition dependency and improving gastrointestinal health in affected patients.
| CAS Number | 2460862-12-6 |
| Molecular Formula | C₁₉₁H₂₉₈N₄₆O₅₈ |
| Purity | ≥95% |
| IUPAC Name | 18-[[(1S)-4-[[1-[2-[2-[2-[[(5S)-5-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]-2-methylpropanoyl]amino]-4-carboxybutanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-4-carboxybutanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]propanoyl]amino]propanoyl]amino]-6-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-carbamimidamido-1-[[2-[[(2S)-5-carbamimidamido-1-[[(2S)-4-carboxy-1-[[(1S)-1-carboxy-3-methylbutyl]amino]-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-6-oxohexyl]amino]-2-oxoethoxy]ethoxy]ethylamino]-2-methyl-1-oxopropan-2-yl]amino]-1-carboxy-4-oxobutyl]amino]-18-oxooctadecanoic acid |
| InChI | InChI=1S/C194H302N46O60/c1-22-107(12)157(184(290)213-110(15)162(268)222-136(89-116-92-206-121-54-44-43-53-119(116)121)174(280)224-132(84-103(4)5)175(281)235-155(105(8)9)182(288)221-122(56-47-77-204-191(197)198)164(270)207-94-145(250)214-123(57-48-78-205-192(199)200)168(274)219-129(69-75-153(262)263)171(277)229-138(188(295)296)85-104(6)7)237-176(282)134(86-113-49-37-35-38-50-113)225-170(276)128(68-74-152(260)261)220-169(275)124(55-45-46-76-202-148(253)100-300-82-81-299-80-79-203-189(297)193(18,19)239-144(249)71-65-130(187(293)294)216-143(248)58-41-33-31-29-27-25-23-24-26-28-30-32-34-42-59-149(254)255)217-161(267)109(14)211-160(266)108(13)212-167(273)127(64-70-142(196)247)215-146(251)95-208-165(271)125(66-72-150(256)257)218-172(278)131(83-102(2)3)223-173(279)133(88-115-60-62-118(246)63-61-115)226-179(285)139(97-241)230-181(287)141(99-243)231-183(289)156(106(10)11)236-178(284)137(91-154(264)265)227-180(286)140(98-242)232-186(292)159(112(17)245)238-177(283)135(87-114-51-39-36-40-52-114)228-185(291)158(111(16)244)234-147(252)96-209-166(272)126(67-73-151(258)259)233-190(298)194(20,21)240-163(269)120(195)90-117-93-201-101-210-117/h35-40,43-44,49-54,60-63,92-93,101-112,120,122-141,155-159,206,241-246H,22-34,41-42,45-48,55-59,64-91,94-100,195H2,1-21H3,(H2,196,247)(H,201,210)(H,202,253)(H,203,297)(H,207,270)(H,208,271)(H,209,272)(H,211,266)(H,212,273)(H,213,290)(H,214,250)(H,215,251)(H,216,248)(H,217,267)(H,218,278)(H,219,274)(H,220,275)(H,221,288)(H,222,268)(H,223,279)(H,224,280)(H,225,276)(H,226,285)(H,227,286)(H,228,291)(H,229,277)(H,230,287)(H,231,289)(H,232,292)(H,233,298)(H,234,252)(H,235,281)(H,236,284)(H,237,282)(H,238,283)(H,239,249)(H,240,269)(H,254,255)(H,256,257)(H,258,259)(H,260,261)(H,262,263)(H,264,265)(H,293,294)(H,295,296)(H4,197,198,204)(H4,199,200,205)/t107-,108-,109-,110-,111+,112+,120-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,155-,156-,157-,158-,159-/m0/s1 |
| InChIKey | KGGWDPBPCUCERE-BGWQDBCCSA-N |
| SMILES | CC[C@H](C)[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)C(C)(C)NC(=O)CC[C@@H](C(=O)O)NC(=O)CCCCCCCCCCCCCCCCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)N)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC5=CC=CC=C5)NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@H](CC6=CNC=N6)N |
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