For research use only. Not for therapeutic Use.
USP30 inhibitor 11(CAT: I045971) is a potent and selective small-molecule inhibitor of ubiquitin-specific peptidase 30 (USP30), with an IC₅₀ of 0.01 μM. Identified as example 83 in patent WO2017009650A1, this compound effectively suppresses USP30’s deubiquitylating activity in biochemical assays. USP30, a 517-amino acid protein localized to the mitochondrial outer membrane, is the only DUB bearing a mitochondrial targeting signal and plays a key role in regulating mitochondrial protein turnover. USP30 inhibitor 11 is widely applied in cancer research and studies of mitochondrial dysfunction, serving as a valuable probe for investigating mitophagy and ubiquitin-mediated quality control.
| CAS Number | 2067332-64-1 |
| Synonyms | (2S)-1-cyano-N-[4-(6-cyano-5-methoxypyridin-2-yl)-1,3-thiazol-2-yl]-N-methylpyrrolidine-2-carboxamide |
| Molecular Formula | C17H16N6O2S |
| Purity | ≥95% |
| IUPAC Name | (2S)-1-cyano-N-[4-(6-cyano-5-methoxypyridin-2-yl)-1,3-thiazol-2-yl]-N-methylpyrrolidine-2-carboxamide |
| InChI | InChI=1S/C17H16N6O2S/c1-22(16(24)14-4-3-7-23(14)10-19)17-21-13(9-26-17)11-5-6-15(25-2)12(8-18)20-11/h5-6,9,14H,3-4,7H2,1-2H3/t14-/m0/s1 |
| InChIKey | APFKLZAHDDDAOH-AWEZNQCLSA-N |
| SMILES | CN(C1=NC(=CS1)C2=NC(=C(C=C2)OC)C#N)C(=O)C3CCCN3C#N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
