Urolithin A - CAS 1143-70-0

Urolithin A (CAS 1143-70-0)is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties. It decreases proliferation in ECC-1, Ishikawa, and HEC-1A human endometrial cancer cell lines at a concentration of 1 M, arrests the cell cycle at the G2/M transition, and modulates estrogen receptor-regulated gene expression. It also potentiates the antiproliferative effect of 5-fluorouracilin Caco-2, SW480, and HT-29 cells. In a rat model of colitis, urolithin A reduces inflammation, decreasing prostaglandin E2 (PGE2) levels and preventing upregulation of COX-2 gene expression and protein levels in colonic mucosa. It also induces mitophagy in C. elegans, C2C12 myoblasts, and Mode-K intestinal cells in correlation with improved fitness and extended lifespan in C. elegans and increased exercise capacity in mice.It has been demonstrated to stimulate mitophagy and improve muscle health in old animals and in preclinical models of aging.

Catalog Number: R022477

CAS Number: 1143-70-0

PubChem Substance ID:355036651

Molecular Formula: C13H8O4

Molecular Weight:228.2

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

Synonyms3,8-Hydroxydibenzo-α-pyrone; 3,8-Dihydroxyurolithin; 2’,7-Dihydroxy-3,4-benzocoumarin; δ-Lactone 2’,4,4’-Trihydroxy-2-biphenylcarboxylic Acid

Property

Molecular Formula: C13H8O4
Molecular Weight228.2
Purity≥95%
Storage-20°C

Computed Descriptor

IUPAC Name3,8-dihydroxybenzo[c]chromen-6-one
InChIInChI=1S/C13H8O4/c14-7-1-3-9-10-4-2-8(15)6-12(10)17-13(16)11(9)5-7/h1-6,14-15H
InChIKeyRIUPLDUFZCXCHM-UHFFFAOYSA-N
SMILESC1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O