For research use only. Not for therapeutic Use.
Uprifosbuvir (Cat No.:I009961) is an investigational antiviral agent developed by Merck for the treatment of chronic hepatitis C virus (HCV) infection. As a nucleotide analog, it functions as a prodrug that inhibits the NS5B RNA-dependent RNA polymerase, a crucial enzyme for viral replication. Uprifosbuvir has demonstrated broad-spectrum activity against HCV genotypes 1 through 6 and has been evaluated in combination with other direct-acting antivirals in Phase I–III clinical trials. A new synthesis route has improved its production efficiency, enhancing its accessibility for research and potential therapeutic use.
| CAS Number | 1496551-77-9 |
| Synonyms | propan-2-yl (2R)-2-[[[(2R,3R,4R,5R)-4-chloro-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate |
| Molecular Formula | C22H29ClN3O9P |
| Purity | ≥95% |
| IUPAC Name | propan-2-yl (2R)-2-[[[(2R,3R,4R,5R)-4-chloro-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate |
| InChI | InChI=1S/C22H29ClN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t14-,16-,18-,20-,22-,36-/m1/s1 |
| InChIKey | SFPFZQKYPOWCSI-KHFYHRBSSA-N |
| SMILES | C[C@H](C(=O)OC(C)C)N[P@@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)Cl)O)OC3=CC=CC=C3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
