For research use only. Not for therapeutic Use.
UNC2400（Cat No.:I011054）is a selective small-molecule inhibitor of the histone methyltransferase EZH2, the catalytic subunit of the polycomb repressive complex 2 (PRC2). By blocking EZH2-mediated trimethylation of histone H3 on lysine 27 (H3K27me3), UNC2400 disrupts epigenetic silencing of target genes, reactivating transcriptional programs involved in differentiation and tumor suppression. Researchers use UNC2400 to study chromatin remodeling, cancer progression, and epigenetic regulation in developmental biology. Its defined selectivity and potency make it a valuable chemical probe for exploring therapeutic strategies targeting EZH2-driven malignancies and other epigenetic disorders.
| CAS Number | 1433200-49-7 |
| Synonyms | N-[(1,6-dimethyl-2-oxo-4-propylpyridin-3-yl)methyl]-N-methyl-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide |
| Molecular Formula | C35H47N7O2 |
| Purity | ≥95% |
| IUPAC Name | N-[(1,6-dimethyl-2-oxo-4-propylpyridin-3-yl)methyl]-N-methyl-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide |
| InChI | InChI=1S/C35H47N7O2/c1-9-10-26-17-25(6)39(8)35(44)31(26)22-38(7)34(43)29-18-28(19-32-30(29)21-37-42(32)24(4)5)27-11-12-33(36-20-27)41-15-13-40(14-16-41)23(2)3/h11-12,17-21,23-24H,9-10,13-16,22H2,1-8H3 |
| InChIKey | IFSQHIRDVVFJSQ-UHFFFAOYSA-N |
| SMILES | CCCC1=C(C(=O)N(C(=C1)C)C)CN(C)C(=O)C2=C3C=NN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)C(C)C)C(C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
