UNC2327

• CAT Number: I011089
• CAS Number: 1426152-53-5
• Molecular Formula: C14H17N5O2S
• Molecular Weight: 319.38
• Purity: ≥95%
• Synonyms: 1-(1,2,3-benzothiadiazol-6-yl)-3-(2-oxo-2-piperidin-1-ylethyl)urea
• InChI: InChI=1S/C14H17N5O2S/c20-13(19-6-2-1-3-7-19)9-15-14(21)16-10-4-5-11-12(8-10)22-18-17-11/h4-5,8H,1-3,6-7,9H2,(H2,15,16,21)
• InChIKey: MYTRGTBDVGKKRO-UHFFFAOYSA-N
• SMILES: C1CCN(CC1)C(=O)CNC(=O)NC2=CC3=C(C=C2)N=NS3

UNC2327（Cat No.:I011089）is a selective inhibitor of the protein kinase TTK (also known as Mps1), which plays a critical role in regulating the spindle assembly checkpoint during cell division. By inhibiting TTK, UNC2327 disrupts proper chromosome alignment and segregation, leading to cell cycle arrest and potentially inducing cell death in cancer cells. This makes UNC2327 a promising candidate for cancer therapy, particularly for tumors with dysregulated mitotic checkpoints. Preclinical studies suggest its potential in enhancing chemotherapy efficacy, though further clinical trials are needed to assess its safety and therapeutic effectiveness in oncology.