UNC1999 - CAS 1431612-23-5

UNC1999 (CAT: I001657) is a potent inhibitor of the lysine methyltransferases EZH2 (Enhancer of Zeste Homolog 2) and EZH1 (Enhancer of Zeste Homolog 1). It competitively binds to the SAM (S-adenosyl methionine) binding site of EZH2 and EZH1, inhibiting their enzymatic activity. UNC1999 exhibits high selectivity for EZH2 and EZH1 over other methyltransferases and non-epigenetic targets. It reduces the levels of the histone mark H3K27me3, which is associated with gene repression. In preclinical studies, UNC1999 has shown promise in prolonging the survival of mice with MLL-AF9 fusion-positive leukemia.

Catalog Number: I001657

CAS Number: 1431612-23-5

PubChem Substance ID:347751605

Molecular Formula: C₃₃H₄₃N₇O₂

Molecular Weight:569.74

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

SynonymsN-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide

Property

Molecular Formula: C₃₃H₄₃N₇O₂
Molecular Weight569.74
Target:Histone Methyltransferase
Solubility10 mM in DMSO
Purity≥95%
StorageStore at -20° C
IC502 nM(EZH2); 45 nM(EZH1)

Computed Descriptor

InChIInChI=1S/C33H43N7O2/c1-7-8-24-15-23(6)37-33(42)28(24)19-35-32(41)27-16-26(17-30-29(27)20-36-40(30)22(4)5)25-9-10-31(34-18-25)39-13-11-38(12-14-39)21(2)3/h9-10,15-18,20-22H,7-8,11-14,19H2,1-6H3,(H,35,41)(H,37,42)
InChIKeyDPJNKUOXBZSZAI-UHFFFAOYSA-N
SMILESCC1=CC(CCC)=C(CNC(C2=C(C=NN3C(C)C)C3=CC(C4=CN=C(N5CCN(C(C)C)CC5)C=C4)=C2)=O)C(N1)=O