UNC1215 - CAS 1415800-43-9

UNC1215 (Cat.No:I001593) is a potent inhibitor of the histone methyltransferase, EZH2. It selectively targets the catalytic SET domain of EZH2, leading to the inhibition of histone H3 lysine 27 methylation. UNC1215 has shown promise as a valuable tool in epigenetic research and may have implications in cancer therapeutics targeting EZH2-driven pathways.

Catalog Number: I001593

CAS Number: 1415800-43-9

PubChem Substance ID:355049797

Molecular Formula: C32H43N5O2

Molecular Weight:529.7

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

Synonyms[3-anilino-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone

Property

Molecular Formula: C32H43N5O2
Molecular Weight529.7
Target:Bromodomain
SolubilityDMSO: 5 mg/mL, clear
Purity≥95%
StorageStore at -20°C
IC50120 nM (Kd) [1]

Computed Descriptor

IUPAC Name[3-anilino-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone
InChIInChI=1S/C32H43N5O2/c38-31(36-20-12-27(13-21-36)34-16-4-5-17-34)25-10-11-29(30(24-25)33-26-8-2-1-3-9-26)32(39)37-22-14-28(15-23-37)35-18-6-7-19-35/h1-3,8-11,24,27-28,33H,4-7,12-23H2
InChIKeyPQOOIERVZAXHBP-UHFFFAOYSA-N
SMILESO=C(N1CCC(N2CCCC2)CC1)C3=CC=C(C(N4CCC(N5CCCC5)CC4)=O)C=C3NC6=CC=CC=C6