UNC1215

• CAT Number: I001593
• CAS Number: 1415800-43-9
• Molecular Formula: C32H43N5O2
• Molecular Weight: 529.7
• Purity: ≥95%
• Target: Bromodomain
• Solubility: DMSO: 5 mg/mL, clear
• Storage: Store at -20°C
• IC50: 120 nM (Kd) [1]
• IUPAC Name: [3-anilino-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone
• InChI: InChI=1S/C32H43N5O2/c38-31(36-20-12-27(13-21-36)34-16-4-5-17-34)25-10-11-29(30(24-25)33-26-8-2-1-3-9-26)32(39)37-22-14-28(15-23-37)35-18-6-7-19-35/h1-3,8-11,24,27-28,33H,4-7,12-23H2
• InChIKey: PQOOIERVZAXHBP-UHFFFAOYSA-N
• SMILES: O=C(N1CCC(N2CCCC2)CC1)C3=CC=C(C(N4CCC(N5CCCC5)CC4)=O)C=C3NC6=CC=CC=C6

UNC1215 (Cat.No:I001593) is a potent inhibitor of the histone methyltransferase, EZH2. It selectively targets the catalytic SET domain of EZH2, leading to the inhibition of histone H3 lysine 27 methylation. UNC1215 has shown promise as a valuable tool in epigenetic research and may have implications in cancer therapeutics targeting EZH2-driven pathways.

Reference

[1]. James LI, Barsyte-Lovejoy D, Zhong N, et al. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol. 2013 Mar;9(3):184-91. doi: 10.1038/nchembio.1157.