UNC1062

• CAT Number: R020822
• CAS Number: 1350549-36-8
• Molecular Formula: C25H34N6O4S
• Molecular Weight: 514.64
• Purity: ≥95%
• Synonyms: 4-[6-(butylamino)-3-(4-morpholin-4-ylsulfonylphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]cyclohexan-1-ol
• InChI: InChI=1S/C25H34N6O4S/c1-2-3-12-26-25-27-17-22-23(29-31(24(22)28-25)19-6-8-20(32)9-7-19)18-4-10-21(11-5-18)36(33,34)30-13-15-35-16-14-30/h4-5,10-11,17,19-20,32H,2-3,6-9,12-16H2,1H3,(H,26,27,28)
• InChIKey: KAAPXWSYROPAEL-UHFFFAOYSA-N
• SMILES: CCCCNC1=NC=C2C(=NN(C2=N1)C3CCC(CC3)O)C4=CC=C(C=C4)S(=O)(=O)N5CCOCC5

UNC1062 (Cat No.: R020822) is a potent, selective small-molecule Mer receptor tyrosine kinase (MerTK) inhibitor developed for oncology and immunology research. By blocking MerTK activity, UNC1062 disrupts signaling pathways that regulate cell survival, proliferation, efferocytosis, and immune evasion. In preclinical cancer studies, UNC1062 has shown the ability to inhibit tumor progression and enhance antitumor immune responses. It is widely used as a pharmacological probe to study the roles of TAM family kinases (Tyro3, Axl, Mer) in cancer biology, immunity, and therapeutic development.

Reference

[1]. Schlegel J, et al. MERTK receptor tyrosine kinase is a therapeutic target in melanoma. J Clin Invest. 2013;123(5):2257-2267.
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