For research use only. Not for therapeutic Use.
UNC1021 (Cat No.: I042565) is a selective chemical probe that targets G9a and GLP, two lysine methyltransferases involved in the methylation of histone H3 at lysine 9 (H3K9), a modification associated with gene repression. By inhibiting G9a/GLP activity, UNC1021 reduces H3K9 methylation, leading to altered chromatin structure and gene expression. It is primarily used in epigenetic research to study transcriptional regulation, cancer biology, and developmental processes. UNC1021 helps elucidate the role of histone methylation in disease and supports drug discovery efforts in epigenetics.
| CAS Number | 1322591-19-4 |
| Synonyms | [4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone |
| Molecular Formula | C26H38N4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C26H38N4O2/c31-25(29-17-9-23(10-18-29)27-13-1-2-14-27)21-5-7-22(8-6-21)26(32)30-19-11-24(12-20-30)28-15-3-4-16-28/h5-8,23-24H,1-4,9-20H2 |
| InChIKey | HIWUTKCNKODAMJ-UHFFFAOYSA-N |
| SMILES | C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)C(=O)N4CCC(CC4)N5CCCC5 |
| Reference | [1]. James LI, et al. Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3. J Med Chem. 2013 Sep 26;56(18):7358-71. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
