UNC0224(Cat No.:I000722) stands as a potent and selective inhibitor of the G9a enzyme, a key player in epigenetic regulation. With an impressive IC50 of 15 nM in the G9a Thioglo assay, UNC0224 demonstrates its capability to modulate the activity of G9a, a histone methyltransferase that contributes to gene expression and chromatin organization. By selectively targeting G9a, UNC0224 offers a valuable tool for investigating the intricate landscape of epigenetic modifications, potentially leading to novel therapeutic strategies for various diseases, including those rooted in aberrant gene regulation.
Catalog Number | I000722 |
CAS Number | 1197196-48-7 |
Synonyms | 7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine |
Molecular Formula | C26H43N7O2 |
Purity | ≥95% |
Target | Histone Methyltransferase |
Solubility | 10 mM in DMSO |
Storage | Store at 4°C |
IC50 | 15 nM [1] |
IUPAC Name | 7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine |
InChI | InChI=1S/C26H43N7O2/c1-30(2)10-7-17-35-24-19-22-21(18-23(24)34-5)25(27-20-8-13-32(4)14-9-20)29-26(28-22)33-12-6-11-31(3)15-16-33/h18-20H,6-17H2,1-5H3,(H,27,28,29) |
InChIKey | XIVUGRBSBIXXJE-UHFFFAOYSA-N |
SMILES | CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)C)OC)OCCCN(C)C |
Reference | <p style=/line-height:25px/> |