UNC0224 - CAS 1197196-48-7

UNC0224(CAT: I000722) stands as a potent and selective inhibitor of the G9a enzyme, a key player in epigenetic regulation. With an impressive IC50 of 15 nM in the G9a Thioglo assay, UNC0224 demonstrates its capability to modulate the activity of G9a, a histone methyltransferase that contributes to gene expression and chromatin organization. By selectively targeting G9a, UNC0224 offers a valuable tool for investigating the intricate landscape of epigenetic modifications, potentially leading to novel therapeutic strategies for various diseases, including those rooted in aberrant gene regulation.

Catalog Number: I000722

CAS Number: 1197196-48-7

PubChem Substance ID:355039648

Molecular Formula: C26H43N7O2

Molecular Weight:485.7

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

Synonyms7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

Property

Molecular Formula: C26H43N7O2
Molecular Weight485.7
Target:Histone Methyltransferase
Solubility10 mM in DMSO
Purity≥95%
StorageStore at 4°C
IC5015 nM [1]

Computed Descriptor

InChIKeyXIVUGRBSBIXXJE-UHFFFAOYSA-N