UNC0224

  • CAT Number: I000722
  • CAS Number: 1197196-48-7
  • Molecular Formula: C26H43N7O2
  • Molecular Weight: 485.70
  • Purity: ≥95%
Inquiry Now

UNC0224(Cat No.:I000722) stands as a potent and selective inhibitor of the G9a enzyme, a key player in epigenetic regulation. With an impressive IC50 of 15 nM in the G9a Thioglo assay, UNC0224 demonstrates its capability to modulate the activity of G9a, a histone methyltransferase that contributes to gene expression and chromatin organization. By selectively targeting G9a, UNC0224 offers a valuable tool for investigating the intricate landscape of epigenetic modifications, potentially leading to novel therapeutic strategies for various diseases, including those rooted in aberrant gene regulation.


Catalog Number I000722
CAS Number 1197196-48-7
Synonyms

7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

Molecular Formula C26H43N7O2
Purity ≥95%
Target Histone Methyltransferase
Solubility 10 mM in DMSO
Storage Store at 4°C
IC50 15 nM [1]
IUPAC Name 7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
InChI InChI=1S/C26H43N7O2/c1-30(2)10-7-17-35-24-19-22-21(18-23(24)34-5)25(27-20-8-13-32(4)14-9-20)29-26(28-22)33-12-6-11-31(3)15-16-33/h18-20H,6-17H2,1-5H3,(H,27,28,29)
InChIKey XIVUGRBSBIXXJE-UHFFFAOYSA-N
SMILES CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)C)OC)OCCCN(C)C
Reference

<p style=/line-height:25px/>
<br>[1]. Liu F, et al. Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. J Med Chem. 2009 Dec 24;52(24):7950-3.
<br>[2]. Liu F, et al. Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. J Med Chem. 2010 Aug 12;53(15):5844-57.
</p>

Request a Quote