Umifenovir hydrochloride

• CAT Number: I046408
• CAS Number: 131707-23-8
• Molecular Formula: C22H26BrClN2O3S
• Molecular Weight: 513.88
• Purity: ≥95%
• Synonyms: ethyl 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate;hydrochloride
• InChI: InChI=1S/C22H25BrN2O3S.ClH/c1-5-28-22(27)20-18(13-29-14-9-7-6-8-10-14)25(4)17-11-16(23)21(26)15(19(17)20)12-24(2)3;/h6-11,26H,5,12-13H2,1-4H3;1H
• InChIKey: OMZHXQXQJGCSKN-UHFFFAOYSA-N
• SMILES: CCOC(=O)C1=C(N(C2=CC(=C(C(=C21)CN(C)C)O)Br)C)CSC3=CC=CC=C3.Cl

Umifenovir hydrochloride (Cat No.: I046408), also known as Arbidol hydrochloride, is an antiviral drug used primarily in Russia and China to treat and prevent influenza and other respiratory viral infections. It inhibits membrane fusion between the virus and host cell, blocking viral entry and replication. Umifenovir also exhibits immunomodulatory properties, enhancing the body’s antiviral defenses. Administered orally, it is generally well-tolerated, with mild side effects such as nausea or allergic reactions. Its efficacy against other viruses, including coronaviruses, is under ongoing investigation.

Reference

[1]. Boriskin YS, et al. Arbidol: a broad-spectrum antiviral compound that blocks viral fusion. Curr Med Chem. 2008;15(10):997-1005.
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[2]. Liu Q, et al. Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection. Acta Pharmacol Sin. 2013;34(8):1075-1083.
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[3]. Wang X, et al. The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. Cell Discov. 2020;6:28. Published 2020 May 2.
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