For research use only. Not for therapeutic Use.
UK-78282 Hydrochloride(CAT: M134691) is a potent, selective non-competitive antagonist of the NMDA (N-methyl-D-aspartate) receptor, particularly targeting the NR2B subunit. This compound is widely used in neuropharmacological research to investigate excitotoxicity, synaptic plasticity, and neurodegenerative diseases such as Alzheimer’s and Parkinson’s. By modulating NMDA receptor activity, UK-78282 helps elucidate the mechanisms of glutamatergic signaling and calcium-mediated neuronal damage. The hydrochloride salt form enhances solubility and stability for in vitro and in vivo applications. It is a valuable tool in CNS drug discovery and mechanistic studies involving neuronal function and excitatory neurotransmission.
| CAS Number | 136647-02-4 |
| Synonyms | 4-(benzhydryloxymethyl)-1-[3-(4-methoxyphenyl)propyl]piperidine;hydrochloride |
| Molecular Formula | C29H36ClNO2 |
| Purity | ≥95% |
| IUPAC Name | 4-(benzhydryloxymethyl)-1-[3-(4-methoxyphenyl)propyl]piperidine;hydrochloride |
| InChI | InChI=1S/C29H35NO2.ClH/c1-31-28-16-14-24(15-17-28)9-8-20-30-21-18-25(19-22-30)23-32-29(26-10-4-2-5-11-26)27-12-6-3-7-13-27;/h2-7,10-17,25,29H,8-9,18-23H2,1H3;1H |
| InChIKey | ZZSQARULZYQMIG-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(C=C1)CCCN2CCC(CC2)COC(C3=CC=CC=C3)C4=CC=CC=C4.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
