For research use only. Not for therapeutic Use.
UCSF924(CAT: I017402) is a potent and selective dopamine D4 receptor (DRD4) partial agonist with an EC50 of 4.2 nM. It demonstrates high binding affinity for DRD4 (Ki = 3 nM) while exhibiting no measurable affinity for D2, D3, or the F261V/L328F D4 mutant, highlighting its exceptional specificity. UCSF924 shows a 7.4-fold signaling bias toward arrestin recruitment over Gαi/o activation, relative to quinpirole. This unique pharmacological profile makes UCSF924 a valuable research tool for dissecting DRD4 signaling pathways, exploring arrestin-biased modulation, and investigating therapeutic opportunities in neuropsychiatric and neurological disorders linked to dopaminergic dysfunction.
| CAS Number | 1434515-70-4 |
| Synonyms | 6-methyl-2-[(3-phenoxypropylamino)methyl]-1H-quinolin-4-one |
| Molecular Formula | C20H22N2O2 |
| Purity | ≥95% |
| IUPAC Name | 6-methyl-2-[(3-phenoxypropylamino)methyl]-1H-quinolin-4-one |
| InChI | InChI=1S/C20H22N2O2/c1-15-8-9-19-18(12-15)20(23)13-16(22-19)14-21-10-5-11-24-17-6-3-2-4-7-17/h2-4,6-9,12-13,21H,5,10-11,14H2,1H3,(H,22,23) |
| InChIKey | RPHDOVLXDYWDGF-UHFFFAOYSA-N |
| SMILES | CC1=CC2=C(C=C1)NC(=CC2=O)CNCCCOC3=CC=CC=C3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
