For research use only. Not for therapeutic Use.
UCM-1336(CAT: I037787) is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC₅₀ of 2 μM. By targeting ICMT, UCM-1336 disrupts the proper localization of endogenous Ras proteins, resulting in reduced Ras activation. This interference with Ras signaling cascades leads to dual mechanisms of programmed cell death: autophagy and apoptosis. UCM-1336’s ability to impair Ras-driven pathways makes it a valuable tool for investigating Ras-associated malignancies and exploring ICMT as a therapeutic target. Its mechanism highlights the critical role of protein methylation in cellular signaling and cancer progression, providing a promising foundation for anticancer drug development and preclinical research.
| CAS Number | 1621535-90-7 |
| Synonyms | 3-[(3-anilino-3-oxopropyl)-octylamino]-N-phenylpropanamide |
| Molecular Formula | C26H37N3O2 |
| Purity | ≥95% |
| IUPAC Name | I037787 |
| InChI | InChI=1S/C26H37N3O2/c1-2-3-4-5-6-13-20-29(21-18-25(30)27-23-14-9-7-10-15-23)22-19-26(31)28-24-16-11-8-12-17-24/h7-12,14-17H,2-6,13,18-22H2,1H3,(H,27,30)(H,28,31) |
| InChIKey | RHEOHKVMYINBGT-UHFFFAOYSA-N |
| SMILES | CCCCCCCCN(CCC(=O)NC1=CC=CC=C1)CCC(=O)NC2=CC=CC=C2 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
