UCK2 Inhibitor-1

• CAT Number: I042618
• CAS Number: 902289-98-9
• Molecular Formula: C27H21N3O4S
• Molecular Weight: 483.54
• Purity: ≥95%
• Synonyms: 3-[[2-[(9-methyl-2-phenyl-5H-chromeno[2,3-d]pyrimidin-4-yl)sulfanyl]acetyl]amino]benzoic acid
• InChI: InChI=1S/C27H21N3O4S/c1-16-7-5-10-18-14-21-25(34-23(16)18)29-24(17-8-3-2-4-9-17)30-26(21)35-15-22(31)28-20-12-6-11-19(13-20)27(32)33/h2-13H,14-15H2,1H3,(H,28,31)(H,32,33)
• InChIKey: XFGJSMZOKNVCKV-UHFFFAOYSA-N
• SMILES: CC1=C2C(=CC=C1)CC3=C(O2)N=C(N=C3SCC(=O)NC4=CC=CC(=C4)C(=O)O)C5=CC=CC=C5

UCK2 Inhibitor-1 (Cat No.: I042618) is a selective small-molecule inhibitor targeting uridine-cytidine kinase 2 (UCK2), an enzyme involved in the pyrimidine salvage pathway essential for nucleotide biosynthesis. Overexpressed in certain cancers, UCK2 contributes to tumor growth and proliferation by supplying nucleotides for rapid DNA and RNA synthesis. By inhibiting UCK2, this compound disrupts nucleotide metabolism, inducing cytotoxic effects in tumor cells. UCK2 Inhibitor-1 is valuable for studying cancer metabolism and holds potential as a therapeutic agent in targeting metabolically active malignancies.

Reference

[1]. Okesli-Armlovich A, et al. Discovery of small molecule inhibitors of human uridine-cytidine kinase 2 by high-throughput screening. Bioorg Med Chem Lett. 2019 Sep 15;29(18):2559-2564.
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