For research use only. Not for therapeutic Use.
UBX1325（Cat No.:I042873）is an investigational small molecule designed to target and inhibit the protein ubiquitin-specific protease 1 (USP1), which plays a critical role in regulating DNA repair mechanisms, particularly the Fanconi anemia pathway. By inhibiting USP1, UBX1325 disrupts DNA damage repair in cancer cells, making them more susceptible to chemotherapy and other DNA-damaging treatments. This approach holds promise in oncology, particularly for tumors with deficient DNA repair pathways. UBX1325 is currently being studied in clinical trials for its potential to enhance the efficacy of cancer therapies and improve treatment outcomes.
| CAS Number | 2271269-01-1 |
| Synonyms | 5-(4-chlorophenyl)-2-methyl-4-[3-[4-[4-[[4-[[(2R)-1-phenylsulfanyl-4-(4-phosphonooxypiperidin-1-yl)butan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylamino]phenyl]piperazin-1-yl]phenyl]-1-propan-2-ylpyrrole-3-carboxylic acid |
| Molecular Formula | C53H59ClF3N6O10PS3 |
| Purity | ≥95% |
| IUPAC Name | 5-(4-chlorophenyl)-2-methyl-4-[3-[4-[4-[[4-[[(2R)-1-phenylsulfanyl-4-(4-phosphonooxypiperidin-1-yl)butan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylamino]phenyl]piperazin-1-yl]phenyl]-1-propan-2-ylpyrrole-3-carboxylic acid |
| InChI | InChI=1S/C53H59ClF3N6O10PS3/c1-35(2)63-36(3)49(52(64)65)50(51(63)37-12-14-39(54)15-13-37)38-8-7-9-43(32-38)62-30-28-61(29-31-62)42-18-16-40(17-19-42)59-77(71,72)46-20-21-47(48(33-46)76(69,70)53(55,56)57)58-41(34-75-45-10-5-4-6-11-45)22-25-60-26-23-44(24-27-60)73-74(66,67)68/h4-21,32-33,35,41,44,58-59H,22-31,34H2,1-3H3,(H,64,65)(H2,66,67,68)/t41-/m1/s1 |
| InChIKey | FSZILRQCEAUYPL-VQJSHJPSSA-N |
| SMILES | CC1=C(C(=C(N1C(C)C)C2=CC=C(C=C2)Cl)C3=CC(=CC=C3)N4CCN(CC4)C5=CC=C(C=C5)NS(=O)(=O)C6=CC(=C(C=C6)N[C@H](CCN7CCC(CC7)OP(=O)(O)O)CSC8=CC=CC=C8)S(=O)(=O)C(F)(F)F)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
