U0126

• CAT Number: I009917
• CAS Number: 109511-58-2
• Molecular Formula: C18H16N6S2
• Molecular Weight: 380.49
• Purity: ≥95%
• Synonyms: (2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile
• InChI: InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+
• InChIKey: DVEXZJFMOKTQEZ-JYFOCSDGSA-N
• SMILES: C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N

U0126 (Cat No.: I009917) is a selective inhibitor of MEK1 and MEK2, key kinases in the MAPK/ERK signaling pathway, which regulates cell proliferation, differentiation, and survival. By blocking MEK activity, U0126 prevents ERK phosphorylation and downstream signaling, making it a valuable research tool in cancer biology, developmental studies, and signal transduction research. It is widely used in vitro to study the role of MAPK pathways in disease processes. U0126 is not approved for clinical use but is instrumental in preclinical mechanistic studies.

Reference

[1]. Favata MF, et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem. 1998 Jul 17;273(29):18623-32.
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[2]. Droebner K, et al. Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo. Antiviral Res. 2011, 92(2), 195-203.
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[3]. Bessard A, et al. RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo. Oncogene. 2008 Sep 11;27(40):5315-25.
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[4]. Ahnstedt H, et al. U0126 attenuates cerebral vasoconstriction and improves long-term neurologic outcome after stroke in female rats. J Cereb Blood Flow Metab. 2015 Mar;35(3):454-60.
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