U-0521

• CAT Number: I012021
• CAS Number: 5466-89-7
• Molecular Formula: C10H12O3
• Molecular Weight: 180.20
• Purity: ≥95%
• Synonyms: 1-(3,4-dihydroxyphenyl)-2-methylpropan-1-one
• InChI: InChI=1S/C10H12O3/c1-6(2)10(13)7-3-4-8(11)9(12)5-7/h3-6,11-12H,1-2H3
• InChIKey: VDQLKIBLTMPAHI-UHFFFAOYSA-N
• SMILES: CC(C)C(=O)C1=CC(=C(C=C1)O)O

U-0521 (Cat No.: I012021) is a small-molecule inhibitor of ascorbate (vitamin C) transport, acting on the sodium-dependent vitamin C transporter (SVCT). By blocking ascorbic acid uptake, it decreases intracellular vitamin C levels, thereby affecting antioxidant defenses, collagen biosynthesis, and other vitamin C–dependent pathways. U-0521 is mainly used as a biochemical research tool to study vitamin C transport mechanisms, oxidative stress responses, and metabolic regulation. Its application provides valuable insights into the physiological and pathological roles of vitamin C in cellular function.

Reference

[1]. Reches A, et al. Effect of 3′,4′-dihydroxy-2-methyl-propriophenone (U-0521) on catechol-O-methyltransferase activity and on DOPA accumulation in rat red blood cells and corpus striatum. Biochem Pharmacol. 1982;31(21):3415-3418.
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