Tyrphostin AG 490 (Cat.No:I001280) is a selective inhibitor of Janus kinase (JAK) and epidermal growth factor receptor (EGFR) tyrosine kinases. It has been extensively studied for its potential in inhibiting cell proliferation and signaling pathways associated with cancer and inflammatory diseases. Tyrphostin AG 490 holds promise as a targeted therapy in preclinical studies.
| Catalog Number | I001280 |
| CAS Number | 133550-30-8 |
| Synonyms | (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide |
| Molecular Formula | C₁₇H₁₄N₂O₃ |
| Purity | 95% |
| Target | EGFR |
| Solubility | DMSO ≥57mg/mL Water <1.2mg/mL Ethanol ≥8mg/mL |
| Storage | 3 years -20C powder |
| IC50 | 0.1 uM (EGFR)[1]; 10 uM (JAK2) [2] |
| InChI | InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+ |
| InChIKey | TUCIOBMMDDOEMM-RIYZIHGNSA-N |
| SMILES | C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N |
