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Tyrphostin AG 490

Tyrphostin AG 490

  • CAT Number: I001280
  • CAS Number: 133550-30-8
  • Molecular Formula: C₁₇H₁₄N₂O₃
  • Molecular Weight: 294.31
  • Purity: ≥95%
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Tyrphostin AG 490 (Cat.No:I001280) is a selective inhibitor of Janus kinase (JAK) and epidermal growth factor receptor (EGFR) tyrosine kinases. It has been extensively studied for its potential in inhibiting cell proliferation and signaling pathways associated with cancer and inflammatory diseases. Tyrphostin AG 490 holds promise as a targeted therapy in preclinical studies.

Catalog Number I001280
CAS Number 133550-30-8
Molecular Formula

C₁₇H₁₄N₂O₃

Purity 95%
Target EGFR
Solubility DMSO ≥57mg/mL Water <1.2mg/mL Ethanol ≥8mg/mL
Storage 3 years -20C powder
IC50 0.1 uM (EGFR)[1]; 10 uM (JAK2) [2]
InChI InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
InChIKey TUCIOBMMDDOEMM-RIYZIHGNSA-N
SMILES C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N

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