[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat

• CAT Number: M139199
• CAS Number: 198277-54-2
• Molecular Formula: C82H120N20O25
• Molecular Weight: 1785.95
• Purity: ≥95%

[Tyr22] Calcitonin Gene-Related Peptide (CGRP), (22-37), rat, (Cat No.: M139199) is a synthetic peptide fragment derived from the C-terminal region of rat CGRP, with a tyrosine substitution at position 22. CGRP is a neuropeptide involved in vasodilation, pain transmission, and neurogenic inflammation. This modified fragment is used in receptor binding and structure-function studies to investigate CGRP signaling pathways. [Tyr22] CGRP (22–37) aids in exploring therapeutic strategies for migraine, cardiovascular diseases, and other conditions involving CGRP-mediated physiological and pathological processes.

Reference

[1]. Jia S, et al. Calcitonin gene-related peptide enhances osteogenic differentiation and recruitment of bone marrow mesenchymal stem cells in rats. Exp Ther Med. 2019 Aug;18(2):1039-1046.
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[2]. Russell FA, et al. Calcitonin gene-related peptide: physiology and pathophysiology. Physiol Rev. 2014 Oct;94(4):1099-142.
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[3]. Heino P, et al. Binding of CGRP analogs and their effect on adenylate cyclase activity in porcine iris-ciliary body. J Ocul Pharmacol Ther. 1998 Dec;14(6):543-54.
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