TWIK-1/TREK-1-IN-3

• CAT Number: I040695
• CAS Number: 1440532-33-1
• Molecular Formula: C19H27F3N2O2
• Molecular Weight: 372.43
• Purity: ≥95%
• Synonyms: (2S)-1-(4-pyrrolidin-1-ylpiperidin-1-yl)-3-[4-(trifluoromethyl)phenoxy]propan-2-ol
• InChI: InChI=1S/C19H27F3N2O2/c20-19(21,22)15-3-5-18(6-4-15)26-14-17(25)13-23-11-7-16(8-12-23)24-9-1-2-10-24/h3-6,16-17,25H,1-2,7-14H2/t17-/m0/s1
• InChIKey: CGWZNOCWGMKTOS-KRWDZBQOSA-N
• SMILES: C1CCN(C1)C2CCN(CC2)CC(COC3=CC=C(C=C3)C(F)(F)F)O

TWIK-1/TREK-1-IN-3 (Cat No.: I040695) is a selective small-molecule inhibitor targeting the two-pore domain potassium channels TWIK-1 and TREK-1, which are involved in maintaining resting membrane potential and regulating neuronal excitability. By blocking these channels, TWIK-1/TREK-1-IN-3 modulates potassium ion flow, influencing processes such as pain perception, mood regulation, and neuroprotection. It is primarily used in neuroscience research to study the physiological roles of K2P channels and evaluate their potential as therapeutic targets in depression, anesthesia, and neurodegenerative disorders.

Reference

[1]. Lee EH, et al. Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants. Biomed Pharmacother. 2023 Sep;165:115139.. .
[Content Brief]