For research use only. Not for therapeutic Use.
Tulmimetostat(Cat No.:I045091)is an investigational dual inhibitor of enhancer of zeste homolog 1 and 2 (EZH1/2), key components of the polycomb repressive complex 2 (PRC2) involved in epigenetic gene silencing. By blocking EZH1/2 activity, Tulmimetostat reduces trimethylation of histone H3 at lysine 27 (H3K27me3), reactivating tumor suppressor genes and inhibiting cancer cell proliferation. It is being studied for the treatment of hematologic malignancies and solid tumors, particularly those with EZH2 mutations or dysregulated PRC2 activity. Supplied for advanced research in epigenetic modulation and oncology drug development.
CAS Number | 2567686-02-4 |
Synonyms | (2R)-7-chloro-2-[4-(3-methoxyazetidin-1-yl)cyclohexyl]-2,4-dimethyl-N-[(6-methyl-4-methylsulfanyl-2-oxo-1H-pyridin-3-yl)methyl]-1,3-benzodioxole-5-carboxamide |
Molecular Formula | C28H36ClN3O5S |
Purity | ≥95% |
IUPAC Name | (2R)-7-chloro-2-[4-(3-methoxyazetidin-1-yl)cyclohexyl]-2,4-dimethyl-N-[(6-methyl-4-methylsulfanyl-2-oxo-1H-pyridin-3-yl)methyl]-1,3-benzodioxole-5-carboxamide |
InChI | InChI=1S/C28H36ClN3O5S/c1-15-10-23(38-5)21(27(34)31-15)12-30-26(33)20-11-22(29)25-24(16(20)2)36-28(3,37-25)17-6-8-18(9-7-17)32-13-19(14-32)35-4/h10-11,17-19H,6-9,12-14H2,1-5H3,(H,30,33)(H,31,34)/t17?,18?,28-/m1/s1 |
InChIKey | CAAWBLRXQXMGHV-WOLMIXIISA-N |
SMILES | CC1=CC(=C(C(=O)N1)CNC(=O)C2=CC(=C3C(=C2C)O[C@@](O3)(C)C4CCC(CC4)N5CC(C5)OC)Cl)SC |
Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |