Tulmimetostat

For research use only. Not for therapeutic Use.

  • CAT Number: I045091
  • CAS Number: 2567686-02-4
  • Molecular Formula: C28H36ClN3O5S
  • Molecular Weight: 562.12
  • Purity: ≥95%
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Tulmimetostat(Cat No.:I045091)is an investigational dual inhibitor of enhancer of zeste homolog 1 and 2 (EZH1/2), key components of the polycomb repressive complex 2 (PRC2) involved in epigenetic gene silencing. By blocking EZH1/2 activity, Tulmimetostat reduces trimethylation of histone H3 at lysine 27 (H3K27me3), reactivating tumor suppressor genes and inhibiting cancer cell proliferation. It is being studied for the treatment of hematologic malignancies and solid tumors, particularly those with EZH2 mutations or dysregulated PRC2 activity. Supplied for advanced research in epigenetic modulation and oncology drug development.


CAS Number 2567686-02-4
Synonyms

(2R)-7-chloro-2-[4-(3-methoxyazetidin-1-yl)cyclohexyl]-2,4-dimethyl-N-[(6-methyl-4-methylsulfanyl-2-oxo-1H-pyridin-3-yl)methyl]-1,3-benzodioxole-5-carboxamide

Molecular Formula C28H36ClN3O5S
Purity ≥95%
IUPAC Name (2R)-7-chloro-2-[4-(3-methoxyazetidin-1-yl)cyclohexyl]-2,4-dimethyl-N-[(6-methyl-4-methylsulfanyl-2-oxo-1H-pyridin-3-yl)methyl]-1,3-benzodioxole-5-carboxamide
InChI InChI=1S/C28H36ClN3O5S/c1-15-10-23(38-5)21(27(34)31-15)12-30-26(33)20-11-22(29)25-24(16(20)2)36-28(3,37-25)17-6-8-18(9-7-17)32-13-19(14-32)35-4/h10-11,17-19H,6-9,12-14H2,1-5H3,(H,30,33)(H,31,34)/t17?,18?,28-/m1/s1
InChIKey CAAWBLRXQXMGHV-WOLMIXIISA-N
SMILES CC1=CC(=C(C(=O)N1)CNC(=O)C2=CC(=C3C(=C2C)O[C@@](O3)(C)C4CCC(CC4)N5CC(C5)OC)Cl)SC
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