For research use only. Not for therapeutic Use.
TUG-499 (Cat No.: I042481) is a synthetic small-molecule agonist of the free fatty acid receptor 1 (FFAR1, also known as GPR40), which is primarily expressed in pancreatic β-cells. Activation of FFAR1 enhances glucose-stimulated insulin secretion, making TUG-499 a promising candidate for the treatment of type 2 diabetes. Designed to provide potent and selective receptor activation, TUG-499 has been studied in preclinical models for its ability to improve glycemic control without causing hypoglycemia. It contributes to the development of metabolically targeted antidiabetic therapies.
| CAS Number | 1206629-08-4 |
| Synonyms | 3-[4-[2-(2,6-dichloropyridin-4-yl)ethynyl]phenyl]propanoic acid |
| Molecular Formula | C16H11Cl2NO2 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H11Cl2NO2/c17-14-9-13(10-15(18)19-14)6-5-11-1-3-12(4-2-11)7-8-16(20)21/h1-4,9-10H,7-8H2,(H,20,21) |
| InChIKey | GCWBKYDSSJIRNJ-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1CCC(=O)O)C#CC2=CC(=NC(=C2)Cl)Cl |
| Reference | [1]. Elisabeth Christiansen, et al. Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties. J Med Chem. 2011 Oct 13;54(19):6691-703. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
