TUG-424

• CAT Number: I009909
• CAS Number: 1082058-99-8
• Molecular Formula: C18H16O2
• Molecular Weight: 264.32
• Purity: ≥95%
• Synonyms: 3-[4-[2-(2-methylphenyl)ethynyl]phenyl]propanoic acid
• InChI: InChI=1S/C18H16O2/c1-14-4-2-3-5-17(14)12-10-15-6-8-16(9-7-15)11-13-18(19)20/h2-9H,11,13H2,1H3,(H,19,20)
• InChIKey: FODHWOBAQBTTFS-UHFFFAOYSA-N
• SMILES: CC1=CC=CC=C1C#CC2=CC=C(C=C2)CCC(=O)O

TUG-424(CAT: I009909) is a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with an EC50 of 32 nM. It enhances glucose-stimulated insulin secretion significantly at concentrations as low as 100 nM, reaching maximal effect at 3 µM, comparable to palmitate. Notably, TUG-424 reduces basal insulin release at low glucose (2.8 mM), highlighting its glucose-dependent action. Beyond its pharmacological role, TUG-424 serves as a click chemistry reagent, containing an alkyne group for Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). This dual functionality makes TUG-424 valuable for diabetes and obesity research, as well as chemical biology applications involving bioorthogonal labeling.