Tubulin polymerization-IN-56

• CAT Number: I040579
• CAS Number: 2966790-98-5
• Molecular Formula: C22H22ClN3O3
• Molecular Weight: 411.88
• Purity: ≥95%
• Synonyms: 6-(6-methylpyridin-3-yl)-1-(3,4,5-trimethoxyphenyl)indazole;hydrochloride
• InChI: InChI=1S/C22H21N3O3.ClH/c1-14-5-6-16(12-23-14)15-7-8-17-13-24-25(19(17)9-15)18-10-20(26-2)22(28-4)21(11-18)27-3;/h5-13H,1-4H3;1H
• InChIKey: WDNWWTXWTVQXBF-UHFFFAOYSA-N
• SMILES: CC1=NC=C(C=C1)C2=CC3=C(C=C2)C=NN3C4=CC(=C(C(=C4)OC)OC)OC.Cl

Tubulin polymerization-IN-56(CAT: I040579) is a potent small-molecule inhibitor of tubulin polymerization, disrupting microtubule dynamics essential for mitotic spindle formation and cell division. By binding to tubulin and preventing its polymerization into microtubules, this compound induces mitotic arrest and apoptosis in proliferating cells. Tubulin polymerization-IN-56 is particularly valuable for cancer research, where it can be used to study cell cycle regulation, cytoskeletal rearrangement, and antimitotic drug responses. Its mechanism is comparable to that of established microtubule-targeting agents, making it a useful tool for evaluating novel chemotherapeutic strategies and investigating microtubule-dependent processes in both normal and tumorigenic cellular models.