Tuberculosis inhibitor 3

• CAT Number: I045587
• CAS Number: 2219325-28-5
• Molecular Formula: C21H22F6N4O3S
• Molecular Weight: 524.48
• Purity: ≥95%
• Synonyms: 8-nitro-6-(trifluoromethyl)-2-[4-[[4-(trifluoromethyl)piperidin-1-yl]methyl]piperidin-1-yl]-1,3-benzothiazin-4-one
• InChI: InChI=1S/C21H22F6N4O3S/c22-20(23,24)13-3-5-29(6-4-13)11-12-1-7-30(8-2-12)19-28-18(32)15-9-14(21(25,26)27)10-16(31(33)34)17(15)35-19/h9-10,12-13H,1-8,11H2
• InChIKey: UFMNTAVTSIJODG-UHFFFAOYSA-N
• SMILES: C1CN(CCC1CN2CCC(CC2)C(F)(F)F)C3=NC(=O)C4=C(S3)C(=CC(=C4)C(F)(F)F)[N+](=O)[O-]

Tuberculosis inhibitor 3 (Cat No.: I045587) is a small-molecule compound identified as a selective inhibitor of Mycobacterium tuberculosis growth. It targets bacterial pathways essential for survival and replication, showing promise in overcoming resistance to conventional anti-tubercular drugs. By interfering with key enzymatic processes, Tuberculosis inhibitor 3 provides a valuable tool for probing mycobacterial physiology and validating novel therapeutic targets. It has been employed in early-stage drug discovery and microbiological studies aimed at developing new treatment strategies against multidrug-resistant and extensively drug-resistant tuberculosis.

Reference

[1]. Kai Lv, et al. Design, synthesis and antitubercular evaluation of benzothiazinones containing a piperidine moiety. Eur J Med Chem. 2018 May 10;151:1-8.
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