For research use only. Not for therapeutic Use.
TTBK1-IN-2（Cat No.:I044144）is a selective small-molecule inhibitor of tau tubulin kinase 1 (TTBK1), an enzyme implicated in neurodegenerative diseases such as Alzheimer’s and Parkinson’s. TTBK1 phosphorylates tau and tubulin, contributing to tau aggregation and neurofibrillary tangle formation. By inhibiting TTBK1 activity, TTBK1-IN-2 reduces pathological tau phosphorylation, offering a promising strategy for modulating tauopathies. This compound is used in preclinical studies to explore the role of TTBK1 in neuronal dysfunction, microtubule dynamics, and cognitive decline. TTBK1-IN-2 is a valuable research tool in neurobiology and therapeutic development targeting tau-mediated neurodegeneration.
| CAS Number | 2765453-51-6 |
| Synonyms | N-[4-(4-chlorophenoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Molecular Formula | C18H13ClN4O |
| Purity | ≥95% |
| IUPAC Name | N-[4-(4-chlorophenoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| InChI | InChI=1S/C18H13ClN4O/c19-12-1-5-14(6-2-12)24-15-7-3-13(4-8-15)23-18-16-9-10-20-17(16)21-11-22-18/h1-11H,(H2,20,21,22,23) |
| InChIKey | RWRSKMSFZCQDMQ-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1NC2=NC=NC3=C2C=CN3)OC4=CC=C(C=C4)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
