For research use only. Not for therapeutic Use.
TTBK1-IN-1（Cat No.:I044525）is a selective small-molecule inhibitor of tau tubulin kinase 1 (TTBK1), an enzyme implicated in the phosphorylation of tau protein, which plays a central role in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease and frontotemporal dementia. By inhibiting TTBK1, TTBK1-IN-1 reduces abnormal tau phosphorylation and aggregation, potentially preventing neurofibrillary tangle formation. This compound is valuable for studying tauopathies and evaluating TTBK1 as a therapeutic target. TTBK1-IN-1 is used in preclinical research to explore disease-modifying strategies for tau-driven neurodegeneration and cognitive decline.
| CAS Number | 2735015-60-6 |
| Synonyms | (3S)-1-[1-(2-amino-6-methoxypyrimidin-4-yl)pyrrolo[3,2-c]pyridin-6-yl]-3-methylpent-1-yn-3-ol |
| Molecular Formula | C18H19N5O2 |
| Purity | ≥95% |
| IUPAC Name | (3S)-1-[1-(2-amino-6-methoxypyrimidin-4-yl)pyrrolo[3,2-c]pyridin-6-yl]-3-methylpent-1-yn-3-ol |
| InChI | InChI=1S/C18H19N5O2/c1-4-18(2,24)7-5-13-9-14-12(11-20-13)6-8-23(14)15-10-16(25-3)22-17(19)21-15/h6,8-11,24H,4H2,1-3H3,(H2,19,21,22)/t18-/m0/s1 |
| InChIKey | HPJVZSVEIGCFJP-SFHVURJKSA-N |
| SMILES | CC[C@@](C)(C#CC1=CC2=C(C=CN2C3=CC(=NC(=N3)N)OC)C=N1)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
