For research use only. Not for therapeutic Use.
TTA-P2（Cat No.:I044134）is a selective and potent antagonist of T-type calcium channels, particularly Cav3.2 and Cav3.3 subtypes. These low-voltage-activated channels are involved in neuronal excitability, pacemaking activity, and rhythmic oscillations. TTA-P2 is widely used in neuroscience research to study sleep regulation, pain transmission, and absence epilepsy. By blocking T-type calcium currents, it reduces thalamocortical burst firing and has shown sedative and analgesic effects in animal models. TTA-P2’s high selectivity and brain permeability make it a valuable pharmacological tool for dissecting the physiological and pathological roles of T-type calcium channels.
| CAS Number | 1072018-68-8 |
| Synonyms | 3,5-dichloro-N-[[1-[[(4S)-2,2-dimethyloxan-4-yl]methyl]-4-fluoropiperidin-4-yl]methyl]benzamide |
| Molecular Formula | C21H29Cl2FN2O2 |
| Purity | ≥95% |
| IUPAC Name | 3,5-dichloro-N-[[1-[[(4S)-2,2-dimethyloxan-4-yl]methyl]-4-fluoropiperidin-4-yl]methyl]benzamide |
| InChI | InChI=1S/C21H29Cl2FN2O2/c1-20(2)12-15(3-8-28-20)13-26-6-4-21(24,5-7-26)14-25-19(27)16-9-17(22)11-18(23)10-16/h9-11,15H,3-8,12-14H2,1-2H3,(H,25,27)/t15-/m0/s1 |
| InChIKey | DKNDOKIVCXTFHJ-HNNXBMFYSA-N |
| SMILES | CC1(C[C@H](CCO1)CN2CCC(CC2)(CNC(=O)C3=CC(=CC(=C3)Cl)Cl)F)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
