For research use only. Not for therapeutic Use.
TSHR antagonist S37a(CAT:I017555) is a selective small-molecule inhibitor of the thyroid-stimulating hormone receptor (TSHR), a G protein–coupled receptor crucial in regulating thyroid function and growth. By blocking TSHR activation, S37a interferes with cAMP signaling pathways, making it a valuable probe for studying thyroid hormone regulation, hyperthyroidism, and Graves’ disease. This antagonist provides a research tool for investigating TSHR-mediated signaling, receptor pharmacology, and therapeutic potential in autoimmune thyroid disorders and endocrine cancers. With its defined structural scaffold, S37a supports studies in drug discovery and endocrine disease biology, advancing efforts to develop next-generation thyroid-targeted therapeutics.
| CAS Number | 2143452-20-2 |
| Synonyms | (1S,2S,9R,10S,11R,12R,16R)-9,14-diphenyl-3,7-dithia-5,14-diazapentacyclo[9.5.1.02,10.04,8.012,16]heptadec-4(8)-ene-6,13,15-trione |
| Molecular Formula | C25H20N2O3S2 |
| Purity | ≥95% |
| IUPAC Name | (1S,2S,9R,10S,11R,12R,16R)-9,14-diphenyl-3,7-dithia-5,14-diazapentacyclo[9.5.1.02,10.04,8.012,16]heptadec-4(8)-ene-6,13,15-trione |
| InChI | InChI=1S/C25H20N2O3S2/c28-23-18-14-11-15(19(18)24(29)27(23)13-9-5-2-6-10-13)20-17(14)16(12-7-3-1-4-8-12)21-22(31-20)26-25(30)32-21/h1-10,14-20H,11H2,(H,26,30)/t14-,15-,16-,17-,18+,19-,20-/m0/s1 |
| InChIKey | YGFJFPYQZCZNIH-HSXTZPDUSA-N |
| SMILES | C1C2C3C(C1C4C2C(=O)N(C4=O)C5=CC=CC=C5)SC6=C(C3C7=CC=CC=C7)SC(=O)N6 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
