TRV056

• CAT Number: I044235
• CAS Number: 812644-79-4
• Molecular Formula: C52H74N14O13
• Molecular Weight: 1103.23
• Purity: ≥95%
• Synonyms: (3S)-3-amino-4-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
• InChI: InChI=1S/C52H74N14O13/c1-5-29(4)43(49(76)62-37(23-32-25-56-27-59-32)50(77)66-20-10-14-39(66)47(74)63-38(51(78)79)22-30-11-7-6-8-12-30)65-46(73)36(21-31-15-17-33(67)18-16-31)61-48(75)42(28(2)3)64-40(68)26-58-45(72)35(13-9-19-57-52(54)55)60-44(71)34(53)24-41(69)70/h6-8,11-12,15-18,25,27-29,34-39,42-43,67H,5,9-10,13-14,19-24,26,53H2,1-4H3,(H,56,59)(H,58,72)(H,60,71)(H,61,75)(H,62,76)(H,63,74)(H,64,68)(H,65,73)(H,69,70)(H,78,79)(H4,54,55,57)/t29-,34-,35-,36-,37-,38-,39-,42-,43-/m0/s1
• InChIKey: NOMIXRQBVMELPF-IWIOKYJLSA-N
• SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N

TRV056（Cat No.:I044235）is a small-molecule biased ligand that selectively targets the angiotensin II type 1 receptor (AT₁R), promoting G protein–biased signaling while minimizing β-arrestin recruitment. This selective activation enables vasodilatory and cardioprotective effects with reduced adverse outcomes often associated with conventional AT₁R agonists or antagonists. TRV056 is studied for its potential in treating cardiovascular disorders such as hypertension and heart failure. By preserving beneficial signaling pathways and avoiding detrimental ones, TRV056 serves as a valuable research compound in the development of next-generation therapeutics for cardiovascular and renal diseases.