TRV055

• CAT Number: I044236
• CAS Number: 25849-90-5
• Molecular Formula: C42H57N9O9
• Molecular Weight: 831.96
• Purity: ≥95%
• Synonyms: (2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid
• InChI: InChI=1S/C42H57N9O9/c1-5-25(4)36(50-37(54)30(18-27-13-15-29(52)16-14-27)46-39(56)35(24(2)3)49-34(53)21-43)40(57)47-31(20-28-22-44-23-45-28)41(58)51-17-9-12-33(51)38(55)48-32(42(59)60)19-26-10-7-6-8-11-26/h6-8,10-11,13-16,22-25,30-33,35-36,52H,5,9,12,17-21,43H2,1-4H3,(H,44,45)(H,46,56)(H,47,57)(H,48,55)(H,49,53)(H,50,54)(H,59,60)/t25-,30-,31-,32-,33-,35-,36-/m0/s1
• InChIKey: YAJPGWCDYDATRI-DIUSPMSXSA-N
• SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)CN

TRV055（Cat No.:I044236）is a G protein–biased ligand targeting the angiotensin II type 1 receptor (AT₁R), designed to selectively activate beneficial G protein signaling pathways while minimizing β-arrestin-mediated effects. This selective signaling profile aims to enhance therapeutic outcomes such as vasodilation and cardioprotection, with reduced risk of adverse effects like fibrosis and inflammation. TRV055 is investigated in preclinical cardiovascular research for its potential to treat conditions such as hypertension, heart failure, and renal impairment. Its mechanism supports the development of biased agonists as safer, more effective alternatives to traditional AT₁R modulators.