TRV-120027 TFA

• CAT Number: I045974
• Molecular Formula: C45H68F3N13O12
• Molecular Weight: 1040.10
• Purity: ≥95%
• Synonyms: (2R)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C43H67N13O10.C2HF3O2/c1-7-24(4)35(40(63)53-31(19-27-20-47-22-49-27)41(64)56-17-9-11-32(56)38(61)50-25(5)42(65)66)55-37(60)30(18-26-12-14-28(57)15-13-26)52-39(62)34(23(2)3)54-36(59)29(51-33(58)21-46-6)10-8-16-48-43(44)45;3-2(4,5)1(6)7/h12-15,20,22-25,29-32,34-35,46,57H,7-11,16-19,21H2,1-6H3,(H,47,49)(H,50,61)(H,51,58)(H,52,62)(H,53,63)(H,54,59)(H,55,60)(H,65,66)(H4,44,45,48);(H,6,7)/t24-,25+,29-,30-,31-,32-,34-,35-;/m0./s1
• InChIKey: TWQGSTLQYSYFSJ-UAPIXIKHSA-N
• SMILES: CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(C)C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)CNC.C(=O)(C(F)(F)F)O

TRV120027 TFA(CAT: I045974) is a β-arrestin-1–biased agonist of the angiotensin II type 1 receptor (AT1R) that selectively engages β-arrestin pathways while blocking G-protein signaling. This signaling bias promotes the assembly of AT1R–β-arrestin-1–TRPC3–PLCγ complexes, enhances cardiomyocyte contractility, and inhibits angiotensin II–mediated vasoconstriction. In HEK293 cells, TRV120027 TFA increases AT1R–TRPC3 interactions and intracellular Ca²⁺ mobilization via TRPC3, effects blocked by Pyr3. In canine heart failure models, intravenous infusion reduces preload, afterload, vascular resistance, and ventricular workload, while improving cardiac output, renal perfusion, and maintaining GFR. TRV120027 TFA is a promising probe for cardiovascular signaling and acute decompensated heart failure research.