TRPV3 antagonist 74a

• CAT Number: I037564
• CAS Number: 1432051-63-2
• Molecular Formula: C17H17F3N2O2
• Molecular Weight: 338.32
• Purity: ≥95%
• Synonyms: 3-[(S)-hydroxy(pyridin-2-yl)methyl]-1-methyl-3-[4-(trifluoromethyl)pyridin-2-yl]cyclobutan-1-ol
• InChI: InChI=1S/C17H17F3N2O2/c1-15(24)9-16(10-15,14(23)12-4-2-3-6-21-12)13-8-11(5-7-22-13)17(18,19)20/h2-8,14,23-24H,9-10H2,1H3/t14-,15?,16?/m1/s1
• InChIKey: MTJXDHFAWXGXIN-QQFBHYJXSA-N
• SMILES: CC1(CC(C1)(C2=NC=CC(=C2)C(F)(F)F)C(C3=CC=CC=N3)O)O

TRPV3 antagonist 74a (Cat No.: I037564) is a selective small-molecule inhibitor of transient receptor potential vanilloid 3 (TRPV3) channels, calcium-permeable ion channels expressed predominantly in skin keratinocytes and sensory neurons. By blocking TRPV3 activity, it reduces calcium influx, thereby modulating processes involved in thermosensation, pruritus, pain perception, and skin barrier function. TRPV3 antagonist 74a is used in dermatology and neuroscience research to study TRPV3-related signaling and to explore therapeutic strategies for treating chronic itch, inflammatory skin diseases, and neuropathic pain linked to TRPV3 overactivation.

Reference

[1]. Gomtsyan A, et al. Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists. J Med Chem. 2016;59(10):4926-4947.
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[2]. Zhao J, et al. PAR2 Mediates Itch via TRPV3 Signaling in Keratinocytes. J Invest Dermatol. 2020;140(8):1524-1532.
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