For research use only. Not for therapeutic Use.
TRPV2-selective blocker 1 (CAT: I040520) is a selective and potent inhibitor of the transient receptor potential vanilloid 2 (TRPV2) channel, with an IC₅₀ of 6.3 μM. It demonstrates high specificity, showing no significant activity against related TRPV1, TRPV3, or TRPV4 channels. This compound effectively blocks TRPV2-mediated calcium influx in macrophages and inhibits downstream functional responses such as phagocytosis. TRPV2-selective blocker 1 is a valuable pharmacological tool for studying TRPV2-associated signaling in immune regulation, inflammation, and mechanotransduction. Supplied in high purity, it is ideal for use in electrophysiology, calcium imaging, and macrophage function assays in both basic and translational research.
| CAS Number | 2242724-49-6 |
| Synonyms | 5-(1,3-dithiolan-2-ylidene)-4-methyl-5-phenylpentan-2-one |
| Molecular Formula | C15H18OS2 |
| Purity | ≥95% |
| IUPAC Name | 5-(1,3-dithiolan-2-ylidene)-4-methyl-5-phenylpentan-2-one |
| InChI | InChI=1S/C15H18OS2/c1-11(10-12(2)16)14(15-17-8-9-18-15)13-6-4-3-5-7-13/h3-7,11H,8-10H2,1-2H3 |
| InChIKey | RCALJRZMLQRHLX-UHFFFAOYSA-N |
| SMILES | CC(CC(=O)C)C(=C1SCCS1)C2=CC=CC=C2 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
