TRPM4-IN-1

• CAT Number: I037563
• CAS Number: 351424-20-9
• Molecular Formula: C15H11Cl2NO4
• Molecular Weight: 340.16
• Purity: ≥95%
• Synonyms: 4-chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid
• InChI: InChI=1S/C15H11Cl2NO4/c16-9-5-6-10(15(20)21)12(7-9)18-14(19)8-22-13-4-2-1-3-11(13)17/h1-7H,8H2,(H,18,19)(H,20,21)
• InChIKey: CVQCJPCMPGKEDH-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)OCC(=O)NC2=C(C=CC(=C2)Cl)C(=O)O)Cl

TRPM4-IN-1 (Cat No.: I037563) is a selective inhibitor of the transient receptor potential melastatin 4 (TRPM4) channel, a calcium-activated nonselective cation channel involved in membrane depolarization and calcium signaling regulation. By blocking TRPM4 activity, this compound modulates processes such as cardiac conduction, neuronal excitability, and immune cell activation. Researchers use TRPM4-IN-1 to explore cardiovascular physiology, neurological disorders, and immune responses. Its specificity provides a valuable tool for dissecting TRPM4-dependent pathways and developing therapeutic strategies targeting arrhythmias, stroke, autoimmunity, and other TRPM4-related diseases.

Reference

[1]. Lijo Cherian Ozhathil, et al. Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. Br J Pharmacol. 2018 Jun; 175(12): 2504–2519.
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[2]. Clémence Delalande, et al. Optimizing TRPM4 inhibitors in the MHFP6 chemical space. Eur J Med Chem. 2019 Mar 15;166:167-177.
[Content Brief]