Trityl Chloride

• CAT Number: R058188
• CAS Number: 76-83-5
• Molecular Formula: C19H15Cl
• Molecular Weight: 278.78
• Purity: ≥95%
• Synonyms: 1,1’,1’’-(Chloromethylidyne)tris[benzene]; Chlorotriphenylmethane; NSC 435; Triphenylchloromethane; Triphenylmethyl Chloride; Tr-Cl; TrCl
• Storage: -20°C
• IUPAC Name: [chloro(diphenyl)methyl]benzene
• InChI: InChI=1S/C19H15Cl/c20-19(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15H
• InChIKey: JBWKIWSBJXDJDT-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)Cl

Trityl Chloride (CAT: R058188) is a widely used protecting reagent in organic and peptide synthesis, particularly valued for its ability to protect hydroxyl and amino groups under mild conditions. Its bulky trityl group offers excellent stability during multi-step reactions and is easily removed under acidic conditions, ensuring selective deprotection. Commonly applied in solid-phase peptide synthesis (SPPS), Trityl Chloride also plays a role in glycosylation and nucleoside chemistry.