Trimethylsilyl ((trimethylsilyl)oxy)acetate

• CAT Number: L045038
• CAS Number: 33581-77-0
• Molecular Formula: C8H20O3Si2
• Molecular Weight: 220.41
• Purity: ≥95%
• IUPAC Name: trimethylsilyl 2-trimethylsilyloxyacetate
• InChI: InChI=1S/C8H20O3Si2/c1-12(2,3)10-7-8(9)11-13(4,5)6/h7H2,1-6H3
• InChIKey: MAEQOWMWOCEXKP-UHFFFAOYSA-N
• SMILES: C[Si](C)(C)OCC(=O)O[Si](C)(C)C

Trimethylsilyl ((trimethylsilyl)oxy)acetate（Cat No.:L045038）is a silyl-protected derivative of glycolic acid, featuring both a trimethylsilyl ester and a trimethylsilyl ether functional group. This dual silylation enhances volatility and thermal stability, making it particularly useful in gas chromatography and analytical chemistry for derivatizing polar compounds such as sugars, acids, or alcohols. The compound serves as a reagent or intermediate in organic synthesis, where moisture-sensitive protection is needed. Its silyl groups are easily removable under mild acidic or fluoride-mediated conditions, allowing for selective deprotection in multi-step synthetic sequences involving hydroxy and carboxylic acid functionalities.