Trimethylsilyl(trifluoromethane)

• CAT Number: R045449
• CAS Number: 81290-20-2
• Molecular Formula: C4H9F3Si
• Molecular Weight: 142.20
• Purity: ≥95%
• Synonyms: (Trifluoromethyl)trimethylsilane; Reagents, Ruppert’s; Ruppert’s reagent; Trifluoro(trimethylsilyl)methane; Trimethyl(trifluoromethyl)silane; Trimethylsilyl(trifluoromethyl)silane; Trimethylsilyltrifluoromethane
• Storage: Store at RT
• IUPAC Name: trimethyl(trifluoromethyl)silane
• InChI: InChI=1S/C4H9F3Si/c1-8(2,3)4(5,6)7/h1-3H3
• InChIKey: MWKJTNBSKNUMFN-UHFFFAOYSA-N
• SMILES: C[Si](C)(C)C(F)(F)F

Trimethylsilyl(trifluoromethane)(CAT: R045449), also known as trimethyl(trifluoromethyl)silane or Ruppert–Prakash reagent, is a powerful reagent used for the introduction of trifluoromethyl (-CF₃) groups into organic molecules. It features a trifluoromethyl group bonded to a trimethylsilyl group, enabling safe and convenient CF₃ transfer in the presence of a fluoride source such as cesium fluoride or tetrabutylammonium fluoride (TBAF). This reagent is widely utilized in fluorine chemistry, drug discovery, and agrochemical development, as the CF₃ group often enhances metabolic stability, lipophilicity, and bioactivity.