Trimethobenzamide HCl

  • CAT Number: I009885
  • CAS Number: 554-92-7 (HCl salt)
  • Molecular Formula: C21H29ClN2O5
  • Molecular Weight: 424.922
  • Purity: ≥95%
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Trimethobenzamide is an antiemetic used to prevent nausea and vomiting. It is often prescribed for patients with gastroenteritis, medication-induced nausea, and other illnesses. Trimethobenzamide is generally considered the most potent antiemetic that does not have effects on the serotonergic, dopaminergic, or histaminergic systems, so it has a lower likelihood of causing undesired side effects. In the United States, it requires a prescription. Although the specific mechanism through which trimethobenzamide functions is unknown, it is believed to affect the chemoreceptor trigger zone (CTZ) of the medulla oblongata.

Catalog Number I009885
CAS Number 554-92-7 (HCl salt)
Synonyms

Tebamide; Ticon; Tigan; trimethobenzamide; trimethobenzamide monohydrochloride; trade names Tebamide, Tigan.;N-{[4-(2-dimethylaminoethoxy)phenyl]methyl}-3,4,5-trimethoxy-benzamide hydrochloride

Molecular Formula

C21H29ClN2O5

Purity 95%
Solubility Soluble in DMSO, not in water
Storage 0 - 4 °C for short term, or -20 °C for long term
Reference

</br>1:Trimethobenzamide HCl in the treatment of nausea and vomiting associated with antineoplastic chemotherapy. Hurley JD, Eshelman FN.J Clin Pharmacol. 1980 May-Jun;20(5-6 Pt 1):352-6. PMID: 7400373 </br>2:Trimethobenzamide HCL (Tigan)-induced extrapyramidal dysfunction in a neonate. Holmes C, Flaherty RJ.J Pediatr. 1976 Oct;89(4):669-70. No abstract available. PMID: 957017

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