Trimethobenzamide HCl

• CAT Number: I009885
• CAS Number: 554-92-7 (HCl salt)
• Molecular Formula: C21H29ClN2O5
• Molecular Weight: 424.922
• Purity: ≥95%
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term

Trimethobenzamide is an antiemetic used to prevent nausea and vomiting. It is often prescribed for patients with gastroenteritis, medication-induced nausea, and other illnesses. Trimethobenzamide is generally considered the most potent antiemetic that does not have effects on the serotonergic, dopaminergic, or histaminergic systems, so it has a lower likelihood of causing undesired side effects. In the United States, it requires a prescription. Although the specific mechanism through which trimethobenzamide functions is unknown, it is believed to affect the chemoreceptor trigger zone (CTZ) of the medulla oblongata.

Reference

1:Trimethobenzamide HCl in the treatment of nausea and vomiting associated with antineoplastic chemotherapy. Hurley JD, Eshelman FN.J Clin Pharmacol. 1980 May-Jun;20(5-6 Pt 1):352-6. PMID: 7400373 2:Trimethobenzamide HCL (Tigan)-induced extrapyramidal dysfunction in a neonate. Holmes C, Flaherty RJ.J Pediatr. 1976 Oct;89(4):669-70. No abstract available. PMID: 957017