Triciferol

• CAT Number: I045430
• CAS Number: 957214-00-5
• Molecular Formula: C26H39NO4
• Molecular Weight: 429.59
• Purity: ≥95%
• Synonyms: (2E,4E,6R)-6-[(1R,3aS,4E,7aR)-4-[2-[(3R,5R)-3,5-dihydroxycyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-N-hydroxy-4-methylhepta-2,4-dienamide
• InChI: InChI=1S/C26H39NO4/c1-17(6-11-25(30)27-31)13-18(2)23-9-10-24-20(5-4-12-26(23,24)3)8-7-19-14-21(28)16-22(29)15-19/h6-8,11,13,18,21-24,28-29,31H,4-5,9-10,12,14-16H2,1-3H3,(H,27,30)/b11-6+,17-13+,20-8+/t18-,21-,22-,23-,24+,26-/m1/s1
• InChIKey: QOEMKJVIXGOYHR-SYOSPHLFSA-N
• SMILES: CC(C=C(C)C=CC(=O)NO)C1CCC2C1(CCCC2=CC=C3CC(CC(C3)O)O)C

Triciferol (Cat No.: I045430) is a synthetic analog of vitamin D designed to modulate calcium and phosphate homeostasis while potentially offering reduced calcemic side effects compared to native calcitriol. It binds to the vitamin D receptor (VDR), regulating gene expression involved in bone metabolism, immune function, and cellular differentiation. Triciferol has been investigated for applications in osteoporosis, chronic kidney disease-related mineral disorders, and certain dermatological conditions. Its modified structure aims to maintain therapeutic benefits of vitamin D while minimizing risks of hypercalcemia during prolonged treatment.

Reference

[1]. Tavera-Mendoza LE, et al. Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist. Proc Natl Acad Sci U S A. 2008;105(24):8250-8255.
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